Monday, January 18, 2010

Cantabria International Campus (CIC) - Executive Summary

1. CCI Characteristics
Cantabria International Campus (CIC) is internationally unique, viable, participative, strategic and competitive.

Unique.The University of Cantabria (UC) and the Menéndez Pelayo International University (UIMP) present an original consensual model to transform Cantabria into a Region of Knowledge, with a new social and productive structure which is based on value added by knowledge, the university-society relationship and territorial integration.

Viable. CIC is viable because its Vision-Mission can be successfully reached thanks to its scale, which favours interaction of its institutions, teaching and research quality of the University of Cantabria , UIMP internationalization and aggregate agents’ strong commitment.

Participative. CIC promotes UC-UIMP partnership by adding 16 strategic agents. In the scientific and academic field, it has the strong commitment of the Superior Council for Scientific Research (CSIC), the Spanish Oceanography Institute, the State Meteorology Agency, the Marcelino Botín , Comillas or Albeniz Foundations. It has full support from the entrepreneurial fabric in Cantabria and the Santander Bank, which is its international prime example, together with Santander and Torrelavega Town Councils, which are the head offices of its campuses. The Project, which was ratified by the Parliament of Cantabria, has been taken on by the Government of Cantabria, and it has transformed it into the node of its new development model through SODERCAN, the Society for the Development of Cantabria.

Strategic. CIC establishes transversal strategic actions to improve human resources, installations and facilities, knowledge management and organization, and cooperation with the environment, and it strategically concentrates its full potential of excellence by sector in six specializations, whose impact becomes greater through the International Campus of Knowledge Dissemination and Social Development.

Internationally competitive. CIC is the best project for the internationalization of Cantabria, a model for a Campus of competitive excellence in knowledge management in education, research and transfer processes.

2. An Example: International Campus of Water and Energy.CIC capabilities can be seen in the development of the International Campus of Water and Energy, which is unique and in the short term is highly likely to succeed due to its financial viability, its results and international leadership, already consolidated by the Institute of Environmental Hydraulics (IHA). This Campus aims to attain its objectives through strategic actions in:

Improvement in Science and Transfer. It is aimed at attracting talent by generating a critical mass of more than 400 researchers through the aggregation of university groups, institutes, technological centers, OPIS and complementary business research centers. This is specialized in the life cycle of renewable energies in the marine field (water and energy integration), climate change and mitigation, territorial resources and planning, and which is supported by highly unique international research infrastructures, such as 2 unique scientific and technological installations (ICTS), a floating wind weather station and three experimental parks for prototypes (off-shore: tidal and wind, on-shore: wind turbines)

With these resources, the Plan for Renewable Energies is integrated in CIC, bringing together international leading companies such as VESTAS, SIEMENS, ACCIONA, EON, REPOWER and IBERDROLA in the internationally unparalleled Renewable Energy Cluster in the Marine Field, and creating other highly innovative companies such as IDERMAR, (a UC spin-off in floating off-shore wind power).

Improvement in Teaching, with the creation of an international postgraduate degree in marine renewable energies and off-shore engineering within the UC/UIMP/CSIC Post-graduate School. Also with the creation of CITAP (with the State Ports Public Organization), which is a corporate center for professionals in the port sector.

Improvement in Internationalization. The previous plans mean internationalization, such as the connection between the CITAP and the American States Organization, the agreements with the Cornell-Center for a Sustainable Future or the VESTAS and SIEMENS research centers which are linked to important international networks, present in CIC.
Improvement in socio-economic and territorial interaction

This IC is a key element in the economic change in Cantabria, which is based on knowledge, and in its territorial structure. The Institute of Hydraulics, the Great Tank of Maritime Engineering, the Renewable Energy Tower for companies, the Technology Center and the Center for Education and Training in Renewable Energies, as well as research centers of large multinational companies are all located in the Science and Technology Park in the region (PCTCAN). The CITAP head office is on the Magdalena Peninsula and two offshore experimental parks are on the West and East Coast of the region. The IC includes the sea as an essential part in its territory.

3. The Other Five Strategic Areas.CIC focuses on another five areas in which the proposed model is also immediately viable.

The International Campus of Biomedicine and Biotechnology, which is based on a cluster which brings together the capacities of the UC-CSIC aggregation in the Institute of Biomedicine and Biotechnology (IBBTEC) http://www.unican.es/ibbtec located in the PCTCAN, as well as on clinical research carried out in the internationally-recognised Marqués de Valdecilla University Hospital (IFIMAV). This is in the process of becoming an On-line specialist Hospital in collaboration with Harvard University and the MIT.

The cluster brings together more than 500 researchers and technicians, promoting transfer through business partners such as FARMAINDUSTRIA and will set up a center of excellence in Neuro-rehabilitation with the Guttman Institute in Torrelavega.

The International Campus in Banking, Finance and Entrepreneurial Activity has support in the UCEIF Foundation, a result of the University of Cantabria-Santander Bank aggregation (one of the most important banks in the world). From its teaching excellence, with an international network of Master’s Degrees in Banking (The University of Cantabria-Santander Bank, UC-Anahuac University in Mexico, UC-Hassan II University in Casablanca and Sao Paulo Getulio-UC-Vargas Foundation), its educational programmes for doctorates (who are financed by the Government of Mexico as future lecturers in this country), its participation in the CUMex network and the partnership with Wharton , will extend its activity with a Research Institute in Banking.

The development of this International Campus is supported by the construction of a Data Centre by the Santander Bank, one of five which in its international network. This centre and the technological and modeling capacities of Cantabria International Campus (RES-ICTS Altamira Super Computation Node) attract companies such as IBM.

The International Campus of Heritage and Language deals with three important lines:

1) Development of prehistoric research from its comparative advantage: Prehistoric heritage in Cantabria (nine caves are World Heritage), which explains the existence of the International Institute of Prehistoric Research (University of Cantabria-Government of Cantabria and Santander Bank, in coordination with CSIC) and of the Altamira National Museum (Governments of Spain and Cantabria).

2) The improvement in heritage with digitization and diffusion programmes (semantic Web) and its application to enhance it.

3) Teaching of Spanish as a Foreign Languague (ELE), in the field of Comillas Foundation (Governments of Spain and Cantabria, Cervantes Institute, Santander Bank, Telefónica, La Caixa, The University of Cantabria, Menéndez Pelayo International University (UIMP) and Spanish Open University (UNED) and the long tradition of the UIMP University. Guaranteed financing will allow the creation of an ELE Research Institute and the development of training and education programmes for professional sectors in emerging countries (Brazil, China).
 

In addition, Cantabria International Campus incorporates a new campus by restoring the Pontificial Seminary in Comillas.

In addition to these three areas, Cantabria International Campus allows its own objectives of excellence to be carried out and promote the previous ones in another 2 strategic areas:
 

International Campus of Physics and Mathematics. The scientific excellence of more than 200 researchers in the Institute of Physics in Cantabria (IFCA) and the University of Cantabria is projected in collaboration with more than 300 universities or laboratories such as the European Organization for Nuclear Research (CERN), Fermilab, ILL or Agencies such as the European Space Agency (ESA) and materializes in unique applications such as the State Meteorological Agency (AEMET). In Mathematics, the scientific solidness of the groups and their interest in sectors which have a great transfer capacity, such as Computation and Computing Science, makes them ideal for managing and developing the Spanish consortium CONSOLIDER i-MATH and consolidating the International Centre for Mathematical Encounters (CIEM).

International Campus of Technology, which brings together more than 500 researchers with great scientific and technological capacity, shown in multiple European projects, CENIT, PROFIT, in areas such as ICTs, Computing Science and Computation, structural integrity and components or Chemical Technology, projects new centres, through aggregating university groups, governmental centres such as CTC (Sodercan) or companies such as INDRA or Solvay, to encourage research and transfer in their own sector or as a technological support for others.

4. Knowledge dissemination, economic and social developmentAll these research capacities , as well as teaching and on-line capacities, are promoted from the International Campus for Knowledge Dissemination and Social Development thanks to the international scope of the Menéndez Pelayo International University (UIMP), whose activity reaches over more than 10,000 students/year, with a great response and social participation.

For this future Project (Cantabria International Campus) there is an estimated cost (period 2009-12) of 192 Million Euros (15M Euros in staff, 156M Euros in infrastructures and equipment and 21M Euros to carry out the project). Financing foreseen by the Government of Cantabria is 45M Euros, other private and public bodies will give 66M Euros and 81M Euros will be requested in the present and future Campus of Excellence official public announcements.

But this mobilization of resources is relevant to the society in which Cantabria International Campus is immersed because it means:
 

Regional, social and solidarity commitment

Cantabria International Campus contributes to essential structure and planning in the region. On its location, CCI is planned and developed with bio-sustainable criteria, in coordination with Santander and Torrelavega Town Councils, and it contributes to regional structuring with the extension of knowledge to local towns in the region (Comillas, Laredo, Suances, Castro Urdiales, Reinosa…..) which make it known to even the furthest municipality.
 

Cantabria International Campus is interaction of the university with society, promoting activities with specific and vulnerable groups, which range from cultural extensions, employability , equality, health, up to cooperation to development.
 

Development in the framework of an advanced and sustainable economy.

An analysis by the Government of Cantabria shows that thanks to sectors which are connected with Cantabria International Campus (R+D+i, renewable energies, advanced entrepreneurial services) there will be an average 2.6% annual increase in Cantabria in the Gross Domestic Product (PIB) until the year 2020. Their own estimates demonstrate that during the first 4 years (2008-12) this rate will be lower than an average 1.5% increase due to the economic recession. As CCI implementation advances, the social, economic and cultural impact will gradually grow, in external variables (productivity index, employment, activity rate) as well as in internal variables (financing obtained through R+D+i, researchers contracts, creation of spin-offs).

An Internationalized Regional Proyect

Cantabria International Campus coordinates knowledge management of two universities, six science institutes, two science-technology parks with numerous technological centres, six foundations, hospitals and a port. Other companies can also be directly linked to the CCI network, such as Vestas, IBM, Siemens or Telefónica and university centres such as Cornell or Wharton.
















































Friday, January 1, 2010

BACTOCOM

The Intergenomics Group is one of the Contributing Partners of the Bactocom Project

Project Background

The main objective of BACTOCOM is to build a simple computer, using bacteria rather than silicon. Microbes may be thought of as biological "micro-machines" that process information about their own state and the world around them. By sensing their environment, certain bacteria are able to move in response to chemical signals, allowing them to seek out food, for example. They can also communicate with other bacteria, by leaving chemical trails, or by directly exchanging genetic information. We focus on this latter mechanism.

Parts of the internal "program" of a bacterial cell (encoded by its genes, and the connections between them) may be "reprogrammed" in order to persuade it to perform human-defined tasks. By introducing artificial "circuits" made up of genetic components, we may add new behaviours or modify existing functionality within the cell. Existing examples of this include a bacterial oscillator, which causes the cells to periodically flash, and cell-based pollution detectors that can spot arsenic in drinking water. The potential for bio-engineering is huge, but the process itself is made difficult by the noisy, "messy" nature of the underlying material. Bacteria are hard to engineer, as they rarely conform to the traditional model of a computer or device, with well-defined components laid out in a fixed design.

We intend to use the inherent randomness of natural processes to our advantage, by harnessing it as a framework for biological engineering. By allowing our system to evolve, we use natural selection to build new functional biological devices. We begin with a large number of simple DNA-based components, taken from a well-understood toolbox, which may be pieced together inside the cell to form new genetic programs. A population of bacteria then absorbs these components, which may (or may not) affect their behaviour. Crucially, the core of our bacterial computer is made up of engineered microbes that can detect how well they are performing, according to some external measure, such as how well they can flash in time with light pulses.

The better bacteria are allowed to release their program components back into the environment in much larger numbers than the other, less impressive cells. As these "good" components are then increasingly taken up by the population of cells, in a continual cycle, we gradually refine the internal program, until the whole population performs well. There are many potential benefits to this work, from both a biological and computing perspective. By evolving new functional structures, we gain insight into biological systems. This, in turn, may suggest new methods for silicon-based computing, in the way that both evolution and the brain have already done. In building these new bio-devices, we offer a new type of programmable, microscopic information processor that will find applications in areas as diverse as environmental sensing and clean-up, medical diagnostics and therapeutics, energy and security.

http://www.docm.mmu.ac.uk/RESEARCH/ncg/bactocom/index.html

Tuesday, November 10, 2009

CICLO DE CONFERENCIAS BIOTECNOLOGÍA para todo(s)

ver díptico


- Jueves, 12 de noviembre

Transgénicos para todos… ¿o para nadie?

José Antonio López Guerrero

Profesor Titular de Microbiología. Universidad Autónoma

de Madrid.


- Jueves, 19 de noviembre

Aplicaciones de la biotecnología en la investigación biomédica

Fernando Peláez Pérez

Director Programa de Biotecnología. Centro Nacional de Investigaciones Oncológicas (CNIO).


- Jueves, 26 de noviembre

Mesa Redonda

Biocombustibles de segunda generación

Antonio Fernández Medarde

Consejero Delegado. Instituto Biomar S.A., León.

Fernando Gómez de Liaño Aparicio

Director de Nuevos Proyectos. Sniace S.A., Madrid

Gabriel Moncalián Montes

Investigador del Departamento de Biología Molecular. Universidad de Cantabria

Lugar: Paraninfo UC, C/ Sevilla 6. Hora: 20:00 h

Tuesday, September 8, 2009

SynBioNT: A Synthetic Biology Network for Modelling and Programming Cell-Chell Interactions

The field of synthetic biology holds a great promise for the design, construction and development of artificial (i.e. man-made) biological (sub)systems thus offering viable new routes to genetically modified organisms, smart drugs as well as model systems to examine artificial genomes and proteomes. The informed manipulation of such biological (sub)systems could have an enormous positive impact on our societies, with its effects being felt across a range of activities such as the provision of healthcare, environmental protection and remediation, etc.
The basic premise of synthetic biology is that methods commonly used to design and construct non-biological systems, such as those employed in the computational sciences and the engineering disciplines, could also be used to model and program novel synthetic biosystems. Synthetic biology thus lies at the interface of a variety of disciplines ranging from biology through chemistry, physics, computer science, mathematics and engineering.
The overarching aim of this network is to generate new vigorous interactions between the disciplines that impinge (and contribute to) Synthetic Biology by supporting a range of community building activities. These activities will be centred on the specific technical goal of achieving programmable interactions between biological and artificial cells.

By focusing on this specific technical challenge we hope to contribute to bridging the gap between synthetic biology from the top-down (i.e. knocking out or modifying functions of existing cells) and bottom-up synthetic biology, that is, from first principles. We believe that both approaches are important and will have a role to play in the future of synthetic biology, hence a challenge that calls for the interaction between top-down systems (modified cells) and bottom-up systems (chells, protocells) provides the ideal background against which a new research community can be built and sustained.
This network is funded by BBSRC (BB/F01855X/1) with co-funding from EPSRC and ESRC.

http://psiren.cs.nott.ac.uk/projects/synbiont/wiki/WikiStart#WelcometoSynBioNT



Thursday, June 18, 2009

Invited Seminar: Directed Evolution of Enzymes

Friday 19th of June

"Iterative saturation mutagenesis as a method for accelerated directed evolution"
Dr. Pankaj Soni.
Prof. Manfred T. Reetz Group. Max Planck Institut fur Kohlenforschung. Muelheim an der Ruhr. Germany.

"Directed Evolution of enantioselective Hybrid Catalysts"
Dr. Jerome J.-P. Peyralans.
Prof. Manfred T. Reetz Group. Max Planck Institut fur Kohlenforschung. Muelheim an der Ruhr. Germany.

Friday, May 8, 2009

Combating Resistance to Antibiotics (CRAB) Meeting

http://www.unican.es/fltq/eventos/20090511d.htm

CRAB meeting
Santander 11-12 May 2009
Scientific and Social Program
Site of scientific sessions: Escuela Superior de Telecomunicaciones. Universidad de Cantabria (located in Avda. de los Castros), about 15 min walking from the hotel.

Monday 11

9h00 - Fernando de la Cruz / Didier Mazel:
Introductory comments and organization details


WP1: Integrons
9h30 D. Mazel: Integrons here and now
10h00 Z. Baharoglu: SOS induction of integrón-integrase expression by conjugation
10h30 C. Loot: Folding of hairpin attC sites: consequences on integrón recombination
11h00 E. Zechner: Conjugative biofilms in a catheter-associated UTI model.
11h30 Coffee break

WP3: Conjugation
12h00 E. Zechner: Regulation at the relaxosome – T4CP interface.
12h30 G. Moncalián: The R388 relaxase and relaxosome.
12h45 M.P. Garcillán: Plasmid classification by relaxases.
13h00 E. Cabezón: Biochemistry of conjugative coupling proteins.
13h15 I. Aréchaga: Biochemostry of type IV secretion systems ATPases
13.30 F. de la Cruz: Inhibition of conjugation
14h15 Lunch at Restaurante (about 15 min walking from the meeting site)
16h30: CRAB administration meeting and discussion about final report (only for IPs; the other participants have free afternoon and evening)

Tuesday 12
WP2: Transposons
9h30 M. Chandler I
10h00 M. Chandler II
10h30 M. Chandler III
11h00 F. Olatz
11h30 Coffee break

WP4: Stability
12h00 L. Van Melderen: Toxin-antitoxin systems: a lot more than we thought…
12h30 J. Guglielmini : Resurrecting old killers: reconstruction of ancestral toxins from toxin-antitoxin systems.
13h00 P. Gabant : How to Make Antibiotics Obsolete: Use of Bacterial Selection Modules for Efficient Protein Production in E. coli
13h30 F Hayes
14h15 Lunch
16h30: CRAB administration meeting and discussion about final report (only for IPs; the other participants have free afternoon and evening)
18 – 20 h: Guided tour to the city of Santander
21 h: CRAB diner. Restaurante “El Peñón” (San Juan de la Canal)

Saturday, March 28, 2009

Plasmids and plasmid modules as orthogonal devices in Synthetic Biology

ESF-UB Conference in Biomedicine

EUROPEAN CONFERENCE ON SYNTHETIC BIOLOGY (ECSB) II: DESIGN, PROGRAMMING AND OPTIMISATION OF BIOLOGICAL SYSTEMS

The field of synthetic biology holds a great promise for the design, construction and development of biological systems (artificial or modified), by offering viable new routes to ‘genetically modified’ organisms, smart drugs and hybrid computational-biological devices. The informed manipulation of such biological systems could have an enormous positive impact on our societies, with its effects being felt across a range of activities such as the provision of healthcare, environmental protection and remediation to the construction of smarter more ubiquitous bio-integrated computing systems, etc.
The basic premise of synthetic biology is that methods commonly used to build non-biological systems, such as those employed in the computational sciences and the engineering disciplines that can deal with large and complex systems, could also be used to specify, design, implement, test and deploy novel synthetic biosystems. Synthetic biology lies at the interface of a variety of disciplines ranging from biology through chemistry, physics, computer science, mathematics and engineering.
Two communities are emerging within synthetic biology, namely top-down - i.e. knocking out or modifying functions of existing cells, and bottom-up - that is construction of artificial systems from first principles, protocells, etc. The aim of this conference is to generate new vigorous interactions between the disciplines that impinge on (and contribute to) Synthetic Biology, and to bring together in the same context top-down and bottom-up researchers.
ECSB 2009 is the second conference in the series. It will comprise invited talks by internationally known scientists who are leaders in their fields, tutorials to introduce young researchers to Synthetic Biology, contributed talks and posters. We expect this to be a major international and multi-disciplinary scientific and educational event. The conference will be limited to just over 100 participants, in a venue whose environment is highly conducive to networking and scientific interactions.
Some, but not all, of the topics to be presented in the conference include: DNA sequencing and synthesis, chemical and biological networks, computational techniques (modelling, data mining, optimisation) for synthetic biology, minimal genomes, evolution (natural, directed and simulated), origins of life, biological systems, cell cycles and circuits, and infrastructures for synthetic biology, minimal cells.
Conference title: Plasmids and plasmid modules as orthogonal devices in Synthetic Biology
Prof. Fernando de la Cruz. Universidad de Cantabria.

Friday, March 27, 2009

The diversity of conjugative relaxases and its application in plasmid classification


The diversity of conjugative relaxases and its application in plasmid classification
María Pilar Garcillán-Barcia 1 , María Victoria Francia 2 & Fernando de la Cruz 1
1 Departamento de Biología Molecular e Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-IDICAN, Santander, Spain; and 2 Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla e Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), Santander, Spain
Correspondence: Fernando de la Cruz, Departamento de Biología Molecular e Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-IDICAN, C. Herrera Oria s/n, 39011 Santander, Spain. Tel.: +34 942201942; fax: +34 942201945; e-mail: delacruz@unican.es
Editor: Eduardo Rocha
Copyright © 2009 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved
KEYWORDS
plasmid classification • relaxase • bacterial conjugation • type IV secretion system • coupling protein
ABSTRACT
Bacterial conjugation is an efficient and sophisticated mechanism of DNA transfer among bacteria. While mobilizable plasmids only encode a minimal MOB machinery that allows them to be transported by other plasmids, conjugative plasmids encode a complete set of transfer genes (MOB+T4SS). The only essential ingredient of the MOB machinery is the relaxase, the protein that initiates and terminates conjugative DNA processing. In this review we compared the sequences and properties of the relaxase proteins contained in gene sequence databases. Proteins were arranged in families and phylogenetic trees constructed from the family alignments. This allowed the classification of conjugative transfer systems in six MOB families: MOBF, MOBH, MOBQ, MOBC, MOBP and MOBV . The main characteristics of each family were reviewed. The phylogenetic relationships of the coupling proteins were also analysed and resulted in phylogenies congruent to those of the cognate relaxases. We propose that the sequences of plasmid relaxases can be used for plasmid classification. We hope our effort will provide researchers with a useful tool for further mining and analysing the plasmid universe both experimentally and in silico.

Thursday, February 12, 2009

Darwin 200


The 200th anniversary of the birth of Charles Robert Darwin falls on 12 February 2009. No single researcher has since matched his collective impact on the natural and social sciences; on politics, religions, and philosophy; on art and cultural relations. In this landmark year, our Nature news special provides continuously updated news, research and analysis on Darwin's life, his science and his legacy.

http://www.nature.com/news/specials/darwin/index.html